Victorian Consortium for Cell-based Therapies (VCCT) Biological Isolator Facilities

Biological isolator systems for the manufacture of human cell-based therapies.

Contact

Ms. Nicole Bleasdale

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Post author: Nicole Bleasdale. Last update: 30/10/2015 at 2:28 pm by Nicole Bleasdale.

Overview

Custom-built biological isolator systems have been installed by St Vincent’s Institute (SVI) and MIMR-PHI Institute of Medical Research (formerly Monash Institute of Medical Research) within ISO 8 certified cleanrooms.

These facilities are available to access for the manufacture of human cell-based therapies.

The BioSpherix Xvivo isolators provide a sterile, fully contained environment suitable for the processing of human cells and tissue. Each isolator contains three independent cell culture incubators, a centrifuge and a microscope, eliminating the need to perform process steps outside the contained environment. The processing chambers provide the flexibility of cell and tissue manipulation under a range of specific conditions. In addition to temperature control across the isolators, gas levels can be adjusted to optimise processing or culturing requirements for different cell types. The isolators are also equipped with sensors to monitor and control air cleanliness.

Development of these facilities has been funded by Therapeutic Innovation Australia (TIA) under the Australian Government’s Translating Health Discovery program. Additional support in the form of soft infrastructure funding has recently been provided by TIA under the Australian Government’s National Collaborative Research Infrastructure Strategy.

Details

Benefits

These units provide a benefit over the conventional cleanroom model of reduced operational costs, processing times and risk to product; while providing a safer and more comfortable environment for operators.

The Australian Red Cross Blood Service has been working closely with SVI and MIMR-PHI to develop and implement the quality systems necessary to operate the facilities to cGMP guidelines.

Access

The isolators are available for the manufacture of human cell-based therapies.

Any queries in relation to the isolator facilities, including access, are to be directed to the VCCT Operations Manager, Nicole Bleasdale.

Access by fee for service
Access by users external to managing organisation, Access by users internal to managing organisation

People

Ms. Nicole Bleasdale

Ms. Nicole Bleasdale

Facility Manager at ! Other, .

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Location

This facility has multiple nodes

Victorian Consortium for Cell-based Therapies (VCCT) Biological Isolator Facilities at VCCT Biological Isolator Facility – SVI

St Vincent’s Institute of Medical Research. Level 3, O’Brien Institute, 42 Fitzroy Street, Fitzroy, Victoria, .
Node manager: Ms. Nicole Bleasdale. P: 0. E: NBleasdale@redcrossblood.org.au.
The VCCT Biological Isolator – SVI is housed within an ISO Class 8 certified cleanroom located at the O’Brien Institute (St Vincent’s Hospital campus, Fitzroy) and provides a sterile, fully contained environment suitable for the processing of human cells and tissue. The isolator is comprised of 9 modules that provide a complete barrier from environmental and operator-borne contamination. Three independent incubators, a water-cooled centrifuge and a microscope are integrated in to the system to eliminate the need to perform process steps outside the contained environment. The processing chambers provide the flexibility of cell and tissue manipulation under various conditions. In addition to temperature control across the isolator, the levels of oxygen, nitrogen and carbon dioxide can be adjusted to optimise processing or culturing requirements for different cell types. The isolator is also equipped with particle monitoring and volatile organic compound sensors, to enable continual monitoring of air cleanliness.

Victorian Consortium for Cell-based Therapies (VCCT) Biological Isolator Facilities at VCCT Biological Isolator Facility – Monash

Hudson Institute of Medical Research. Cell Care Pty Ltd, 42 Corporate Drive, Heatherton, Victoria, .
Node manager: Ms. Nicole Bleasdale. P: 0. E: NBleasdale@redcrossblood.org.au.
The VCCT Biological Isolator – Monash is temporarily located at Cell Care Pty Ltd while the Monash Health Translational Precinct Translational Research Facility (MHTP-TRF) is being constructed.
The isolator is located within an ISO Class 8 certified cleanroom and provides a sterile, fully contained environment suitable for the processing of human cells and tissue. The isolator is comprised of 8 linked modules that provide a complete barrier from environmental and operator-borne contamination. Three independent incubators, a water-cooled centrifuge and a microscope are integrated in to the system to eliminate the need to perform process steps outside the contained environment. The processing chambers provide the flexibility of processing cells and tissue under various conditions. In addition to temperature control across the isolator, the levels of oxygen, nitrogen and carbon dioxide can be adjusted to optimise processing or culturing requirements for different cell types. The isolator is also equipped with particle monitoring and volatile organic compound sensors, to enable continual monitoring of air cleanliness.

Victorian Consortium for Cell-based Therapies (VCCT) Biological Isolator Facilities at VCCT Biological Isolator Facility – SVI

St Vincent’s Institute of Medical Research, . Level 3, O’Brien Institute, 42 Fitzroy Street, Fitzroy, Victoria, Australia.
Node manager: Ms. Nicole Bleasdale. P: 0. E: NBleasdale@redcrossblood.org.au.

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Categories


Type: Core facility in a research organisation
Discipline areas: Biological Science
Precinct: Northern, South east
Affiliations: Hudson Institute of Medical Research, St Vincents Institute of Medical Research

Biological Science categories: Biobanks, Bioresources, Cell culture, Cells and tissues, Clean rooms, Clinical Trials Design and Managment, Clinical trials resources, Manufacturing, Tissues preparation