HTCS (High-throughput Chemical Screening) Facility

Walter and Eliza Hall Institute of Medical Research, Biotechnology Centre.

Contact

Dr. Hélène Jousset

+61 3 9345 2555


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Post author: Kurt Lackovic. Last update: 02/11/2015 at 10:49 am by Kurt Lackovic.

Overview

The HTCS Facility houses a Lead Discovery library currently containing ~200,000 compounds and robotics platforms to screen these small molecule chemical entities against biological targets of interest for drug discovery or for chemical biology outcomes. It has two core automation systems, the Hamilton MicroSTAR and PerkinElmer Minitrak IX systems as well as a BD Biosciences Pathway HT High Content Screening cell-imager, Biacore S51, MesoScale Discovery Sector Multi-Plex and Roche Applied Science’s xCELLigence Real-Time Cell Analyser. The Facility is capable of both molecular and cell-based screening technologies.

Other infrastructure:

  • HTS database (ActivityBase).
  • WEHI Lead Discovery Library (200,000 synthetic small molecules).
  • Access to vendor collections (10M compounds available).
  • Access to Medicinal Chemistry Consultation or fee-for-service.
  • Drug Discovery resources.

Access by:

  • Research collaboration.
  • Fee for service.

Details

Benefits

Know how:

  • HTS Assay Development resources.
  • HTS Database and Data Handling services.
  • HTS Automation Expertise and Specialists.
  • Novel and emerging technologies awareness and test-site.

Expertise:Availability of technical support:

  • Support for experimental design is available.
  • Support for instrument use is available.

Note that this material was imported form the Victorian Bioportal and content requires updating.

Access
People

Dr. Hélène Jousset

Dr. Hélène Jousset

Facility Manager at Walter and Eliza Hall Institute of Medical Research, .

P: +61 3 9345 2555 | Email |

Instruments
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Location

HTCS (High-throughput Chemical Screening) Facility

Walter and Eliza Hall Institute of Medical Research, . 4 Research Avenue, Bundoora, Victoria, Australia.

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Media

Categories


Type: Core facility in a research organisation
Discipline areas: Biological Science
Precinct: Central, Northern
Affiliations: Walter and Eliza Hall Institute of Medical Research

Biological Science categories: Assay development, Bio-Assay, Bioinformatics, Bioresources, Cell culture, Cells and tissues, Computational, Confocal, Discovery, Drug development, ELISA, FLIPR, Fluorescence, Fragment, Functional assays, High-content systems, High-throughput screening, Live-cell, Luminescence, Medicinal chemistry, Microscopy, Molecular libraries, Proteins and peptides, Quantitative image analysis, RNA, Small molecule libraries