Drug Delivery, Disposition and Dynamics (D4)

Monash Institute of Pharmaceutical Sciences (MIPS).

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Mr. Chris Porter

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Post author: Chris Porter. Last update: 02/11/2015 at 1:50 pm by Anneliese Gillard.

Overview

The Drug Delivery Disposition and Dynamics (D4) Theme at the Monash Institute of Pharmaceutical Sciences provides expertise and infrastructure in drug formulation and drug delivery system design and assessment and evaluation of drug formulations/delivery systems in pre-clinical animal models. The facility has particular expertise in overcoming the challenges associated with oral delivery of poorly absorbed drugs, in facilitating effective pulmonary drug delivery and has a large group dedicated to pharmacokinetic and pharmacodynamic evaluation of novel antiinfectives.

Members of the theme are also skilled in the use of nanoparticulate delivery technologies (nanoparticles, liposomes, dendrimers) to facilitate site specific delivery of, for example, anticancer compounds and macromolecular constructs such as siRNA. We have significant experience with novel drug formulation and delivery system technologies including lipid based formulations for oral and parenteral administration (microemulsions, liposomes, emulsions, micelles); liquid crystalline systems for responsive and controlled delivery and microparticulate dry power delivery technologies for pulmonary delivery. We also have broad experience in more typical drug formulation approaches (solutions, suspensions, spray-dried dispersions, tablets, capsules). Technologically, we have the capacity to evaluate formulation characteristics using colloid and particle characterization techniques including advanced particle sizing and AFM, inverse gas chromatography and thermal methods including ITC and DSC.

D4 typically works collaboratively with industrial or academic groups to address a particular drug delivery challenge, but may provide a fee-for-service function in some cases.

Other infrastructure:

  • Access to small (mouse, rat) and large (dog, sheep) animal models.
  • Cell culture.

Access by:

  • Research collaboration.
  • Fee for service.

Details

Benefits

Know how:

  • Drug Formulation.
  • Bioanalysis.
  • Drug Delivery System Design.
  • Pharmacokinetics and Pharmacodynamics.
  • Design and evaluation of antiinfectives.

Expertise:Availability of technical support:

Note that this material was imported form the Victorian Bioportal and content requires updating.

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People

Mr. Chris Porter

Mr. Chris Porter

Facility Manager at Monash University, .

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Location

Drug Delivery, Disposition and Dynamics (D4)

Monash University, Parkville Campus. 381 Royal Parade, Parkville, Victoria, Australia.

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Type: Core facility in a research organisation
Discipline areas: Biological Science
Precinct: Central
Affiliations: Monash University

Biological Science categories: ADME, Analytical assays, Analytical assays, Bio-Assay, Clinical trials resources, Delivery, Discovery, Drug development, Formulation, HPLC, Mass spectroscopy, Pharmacokinetics, Preclinical assays