Monash Institute of Pharmaceutical Sciences (MIPS).
Post author: Chris Porter. Last update: 02/11/2015 at 1:50 pm by Anneliese Gillard.
The Drug Delivery Disposition and Dynamics (D4) Theme at the Monash Institute of Pharmaceutical Sciences provides expertise and infrastructure in drug formulation and drug delivery system design and assessment and evaluation of drug formulations/delivery systems in pre-clinical animal models. The facility has particular expertise in overcoming the challenges associated with oral delivery of poorly absorbed drugs, in facilitating effective pulmonary drug delivery and has a large group dedicated to pharmacokinetic and pharmacodynamic evaluation of novel antiinfectives.
Members of the theme are also skilled in the use of nanoparticulate delivery technologies (nanoparticles, liposomes, dendrimers) to facilitate site specific delivery of, for example, anticancer compounds and macromolecular constructs such as siRNA. We have significant experience with novel drug formulation and delivery system technologies including lipid based formulations for oral and parenteral administration (microemulsions, liposomes, emulsions, micelles); liquid crystalline systems for responsive and controlled delivery and microparticulate dry power delivery technologies for pulmonary delivery. We also have broad experience in more typical drug formulation approaches (solutions, suspensions, spray-dried dispersions, tablets, capsules). Technologically, we have the capacity to evaluate formulation characteristics using colloid and particle characterization techniques including advanced particle sizing and AFM, inverse gas chromatography and thermal methods including ITC and DSC.
D4 typically works collaboratively with industrial or academic groups to address a particular drug delivery challenge, but may provide a fee-for-service function in some cases.
- Access to small (mouse, rat) and large (dog, sheep) animal models.
- Cell culture.
- Research collaboration.
- Fee for service.
- Drug Formulation.
- Drug Delivery System Design.
- Pharmacokinetics and Pharmacodynamics.
- Design and evaluation of antiinfectives.
Expertise:Availability of technical support:
Note that this material was imported form the Victorian Bioportal and content requires updating.