Centre for Drug Candidate Optimisation (CDCO)

Monash Institute of Pharmaceutical Sciences

Contact

Dr. Andrew Powell

(03) 9903 9149


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Post author: Andrew Powell. Last update: 28/08/2015 at 11:44 am by Andrew Powell.

Overview

The Centre for Drug Candidate Optimisation (CDCO) is a collaborative research centre based within Monash University’s Institute of Pharmaceutical Sciences (MIPS) that provides ADME lead candidate optimisation expertise and infrastructure to support emerging drug discovery programs.

Drug candidate optimisation fills a crucial gap between discovery and development by integrating pharmacokinetic properties into medicinal chemistry and biology programs to provide a rational means of identifying drug candidates suitable for progression into preclinical and clinical development. This process has become an essential, value-creating component of modern drug discovery.

The CDCO’s expertise encompasses the disciplines of physical and preformulation chemistry, pharmacokinetics, drug metabolism and bioanalysis by LCMS to provide the necessary platforms for rapid identification of developmental properties. Research is performed to industry standards and flexible study designs can implement to suit the needs of individual drug discovery programs.

The CDCO collaborates with Australian and international drug discovery groups covering a spectrum of commercial and not-for-profit organisations, research institutes and universities.

Details

Benefits

Core areas of expertise:

  • Physicochemical profiling
  • Drug permeability
  • Drug metabolism and metabolite profiling
  • Metabolic drug-drug interactions
  • Bioavailability and pharmacokinetics
  • Preclinical formulation development
  • Early stage solid state characterisation and salt selection
  • Stability testing and impurity profiling
  • Quantitative bioanalysis by LCMS
Access

The CDCO operates on a not-for-profit, cost-recovery model. Our fees cover salaries and consumable expenses and contribute to the maintenance and upgrading of equipment to ensure our sustainability.

We provide expertise and validated platforms to support drug discovery programs through:

  • flexible contractual arrangements
  • customised project structure
  • collaborative working relationships
  • clear ownership of all project-related intellectual property residing with the collaborator.

A project coordinator is assigned to each collaborative study and acts as the primary point of contact for the management of project activities. Project management occurs on several levels to deliver timely, high-quality results.


Program participation: Innovation Voucher Supplier, Technology Voucher Supplier
Access by collaboration, Access by fee for service
Access by users external to managing organisation, Access by users internal to managing organisation

People

Professor Susan Charman

Professor Susan Charman

Director at Monash University, Parkville Campus.

Email |

Dr. Andrew Powell

Dr. Andrew Powell

Operations Manager at Monash University, Parkville Campus.

P: (03) 9903 9149 | Email |

Services

Bioanalysis by LCMS

Used for the quantitation of novel small molecule drug candidates in biological samples.

Facility contact: |

Drug metabolism and metabolite identification

Used for the assessment of metabolic stability of drug candidates and identification of breakdown products.

Facility contact: |

In vitro ADME profiling

Used for the assessment of biorelevant solubility, permeability and partitioning properties of compounds.

Facility contact: |

In vivo pharmacokinetics

Used for the definition of the plasma concentration time profile of a novel drug candidate.

Facility contact: |

Physicochemical profiling

Used for the assessment of drug-like properties of novel drug candidates.

Facility contact: |

Location

Centre for Drug Candidate Optimisation (CDCO)

Monash University, Parkville Campus. 381 Royal Parade, Parkville, Victoria, Australia.

View location in Google maps. This location is based upon GPS coordinates as the street address does not accurately indicate the location of the facility.

Categories


Type: Core facility in a research organisation, Research center
Discipline areas: Pharmaceutical Science
Precinct: Northern
Affiliations: Monash Institute of Pharmaceutical Sciences, Monash University

Tags: ADME, DMPK, drug discovery, formulation, HPLC, LCMS, mass spectrometry, metabolism, metabolite identification, pharmacokinetics