The CSIRO Collaborative Crystallisation Centre (C3) is a full service protein crystallisation centre specialising in both screening and optimisation. C3 provides both expert and novice users access to technologies which will enable the rapid and efficient sampling of crystallisation space. Our core competency is high-throughput small volume (sub-microlitre) dispensing coupled with automatic imaging, but our strength lies in our ease of use, range of services and expert advice.

Virtual screening to facilitate structure-based drug design

The Australian Synchrotron is a source of highly intense light ranging from infrared to hard x-rays used for a wide variety of research purposes. Officially opened in July 2007, the Australian Synchrotron is one of fewer than 40 similar facilities around the world. It is the largest stand-alone piece of [...]

X-ray diffraction provides a key methodology for determining the three dimensional structure of biological macromolecules to atomic or near atomic detail. However, before an X-ray diffraction experiment can be performed crystals of the molecule of interest are required. Efficient production of high-quality protein crystals for structure determination is one of [...]