X-ray diffraction provides a key methodology for determining the three dimensional structure of biological macromolecules to atomic or near atomic detail. However, before an X-ray diffraction experiment can be performed crystals of the molecule of interest are required. Efficient production of high-quality protein crystals for structure determination is one of [...]
Crystallisation technologies, including robotic high-throughput
The CSIRO Collaborative Crystallisation Centre (C3) is a full service protein crystallisation centre specialising in both screening and optimisation. C3 provides both expert and novice users access to technologies which will enable the rapid and efficient sampling of crystallisation space. Our core competency is high-throughput small volume (sub-microlitre) dispensing coupled with automatic imaging, but our strength lies in our ease of use, range of services and expert advice.