Burnet Antiviral Screening

Burnet Institute

Contact

Assoc. Professor Gilda Tachedjian

(613) 9282 2256


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Post author: Gilda Tachedjian. Last update: 02/11/2015 at 12:08 pm by Gilda Tachedjian.

Overview

The Antiviral Screening Facility has the capacity to test chemical agents for their ability to inhibit the replication of HIV and herpes simplex (HSV) type 1 and 2 viruses in cell culture based assays and to elucidate their mechanism of action. This means that researchers can accelerate the development of new methods that may lead to better treatments for these chronic infections. The team has extensive experience in basic research and in particular in understanding the biology of retroviruses. All work undertaken by the facility is guided by principles outlined in the FDA guidelines for Antiviral Product Development.

 

Details

Benefits

The Burnet Antiviral Screening Facility can perform the following:

  • Screen compounds for activity against a laboratory strain of human immunodeficiency virus type 1 (HIV-1) in cell culture based assays including determination of selectivity index (SI) of compounds (SI= 50% effective concentration/ 50% cytotoxic concentration)
  • Evaluate activity of compounds against different HIV strains including distinct HIV subtypes and clinical isolates in cell lines and in primary cells.
  • Test agents for ability to inhibit HIV strains resistant to drugs used in the clinic
  • Evaluate mechanism of action of HIV inhibitors
  • Select and characterise drug-resistant strains of HIV
  • Evaluate antiviral activity in cell culture based assays in the presence of serum, seminal plasma, cervicovaginal secretions.
  • Screen compounds for activity against HSV-1 and HSV-2 in cell culture assays including determination of selectivity index (SI) of compounds
Access

For more information please contact the Facility Head: A/Prof Gilda Tachedjian, (03) 9282 2256, gildat@burnet.edu.au

Access by collaboration, Access by fee for service
Access by users external to managing organisation, Access by users internal to managing organisation

Location

Burnet Antiviral Screening

Burnet Institute. 85 Commercial Rd, Melbourne, Victoria, VIC.

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Media

Categories


Type: Research laboratory
Discipline areas: Biological Science
Precinct: Central, South east
Affiliations: Burnet Institute
Accreditation: AQIS
Biological Science categories: Discovery, Drug development, High-throughput screening