Two biological isolator facilities have been established to facilitate clinical development of human cell-based therapies. Established under the auspices of the Victorian Consortium for Cell-based Therapies (VCCT), the isolators provide a complete barrier from environmental and operator-borne contamination and are therefore ideally suited for aseptic processing.
X-Ray Crystallography supports structural biology and rational drug design
VLSCI is the biggest computation facility devoted to life sciences in the world, where researchers can access high-end compute resources and a range of experts to assist them - from research design through to data management and interpretation.
The SVI Flow Cytometry Facility supports a wide range of flow cytometric applications such as DNA analysis, immuno-phenotyping, lymphocyte function assessment, apoptosis and proliferation assays, just to name a few.
Virtual screening to facilitate structure-based drug design
Observation of cells non-invasively in animals making it a very useful tool for work on bone biology.
The facility is equipped for patch-clamp electrophysiology, allowing plasma-membrane ion-channel or transporter activity to be recorded in whole-cell or excised membrane patch configurations,
The Zetasizer Nano ZS (Malvern Instruments, UK) instrument uses light scattering techniques to determine the size distribution profile of particles in suspension.
The CD spectromometer shines polarised light at proteins and allows analysis of protein secondary structure from circular dichroism spectra and aids monitoring of protein folding and conformational changes prior to using more expensive and time consuming methods such as NMR and X-ray crystallography