Used for the definition of the plasma concentration time profile of a novel drug candidate
Post author: Andrew Powell. Last update: 13/03/2014 at 12:13 pm by Andrew Powell.
In vivo pharmacokinetics characterises the absorption, distribution, metabolism and excretion (ADME) properties of a drug candidate, allowing identification of limiting features in relation to the desired route of administration. Coupled with the results from in vitro screens, in vivo pharmacokinetic data enables the early identification of compound liabilities, providing a basis for structural modifications or for the early initiation of development strategies to overcome these problems.
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