Used for the assessment of biorelevant solubility, permeability and partitioning properties of compounds
Post author: Andrew Powell. Last update: 13/03/2014 at 12:12 pm by Andrew Powell.
The absorption, distribution, metabolism and excretion (ADME) of drug candidates are critical parameters that dictate the route and frequency of administration. The CDCO utilises in silico and in vitro methodologies to assess relevant ADME properties, including membrane permeability, the role of transporters in limiting absorption, plasma protein binding, solubility in physiologically relevant media, and stability in biological matrices. Assessing these properties early in discovery provides a mechanistic understanding of relevant developmental properties.
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